Neuroscience – Addiction and the Brain



Addiction is a complex disorder that can be defined as a “loss of control over a reward-seeking behaviour” (Robert West, 2006). According to Kolb and Volkow …

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  1. The true science of addiction(substance, sex,food,gambling,etc..) is the Nuclear phosphoprotein Fos proto-oncogene. In the FOS family there are 4 genes.

    DeltaFosB is a truncated splice variant of the FOSB gene(shortened coding sequence of genes that highly effect gene function.)

    Anyway deltafosB is basically the brains molecular switch for addiction and various transcription factors like c-fos, CREB, deltaCREB, C/EBPbeta, AP-1, c-Jun and ep300 (or p300/Histone Acetyltransferace) which all effect gene expression as well.

    It’s basically your brain learning to only function is this is this is this substance or action that renders many people (especially those with genetic mutations in the pathway) helpless as they cannot “try” or “want” to quit as their brain simply WILL NOT let them.

    This is all obvious with our knowledge of genetics and epigenetics and should be pretty easy for science as they had plenty of time to develop novel compounds to counteract addiction but it seems they are slacking.

    More focus needs to be put into other important areas besides the obvious dopamine, serotonin, NE, Gaba,etc.. more focus need to be on histone deacetylase inhibition, phosphodiesterase inhibition, regulation of Tyrosine Hydroxylase, wayyyy more research on Orexin and it’s Hypocretin receptors, more NMDA regulators, Calcium/calmodulin dependent protein kinases, Cell division protein kinases, Peroxisome proliferator activated receptor (PPAR) signaling, Trace amine associated receptors, Vanilloid receptors(hardly anything on this which is negligent as it relates to endorphins), much more on adrenergic receptors, vesicular monoamine transporters, Wnt signaling, VEGF signaling, and definitely more on melatonergic agonism as the circadian rhythm regulates everything.

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